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7-O-Demethyl rapamycin

Catalog No. T25882 CAS 151519-50-5

Synonyms: CJ 12263, CJ12263, 7-O-Demethyl Rapammune, Novolimus (80%), 7-O-Demethyl Cypher, Novolimus, CJ-12263

Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

7-O-Demethyl rapamycin Chemical Structure

7-O-Demethyl rapamycin, CAS 151519-50-5

Pack Size	Availability	Price/USD	Quantity
5 mg	Inquiry	$ 1,345.00
10 mg	Inquiry	$ 2,245.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Novolimus is a macrocyclic lactone with anti-proliferative properties. It has similar efficacy to currently available agents but requires a lower dose.

Synonyms	CJ 12263, CJ12263, 7-O-Demethyl Rapammune, Novolimus (80%), 7-O-Demethyl Cypher, Novolimus, CJ-12263
Molecular Weight	900.16
Formula	C50H77NO13
CAS No.	151519-50-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Wiebe J, Bauer T, Dörr O, Möllmann H, Hamm CW, Nef HM. Implantation of a novolimus-eluting bioresorbable scaffold with a strut thickness of 100 µm showing evidence of self-correction. EuroIntervention. 2015 Jun;11(2):204. doi: 10.4244/EIJY15M02_01. PubMed PMID: 25671516. 2. Iqbal J, Verheye S, Abizaid A, Ormiston J, de Vries T, Morrison L, Toyloy S, Fitzgerald P, Windecker S, Serruys PW. DESyne novolimus-eluting coronary stent is superior to Endeavor zotarolimus-eluting coronary stent at five-year follow-up: final results of the multicentre EXCELLA II randomised controlled trial. EuroIntervention. 2016 Dec 10;12(11):e1336-e1342. doi: 10.4244/EIJY15M10_04. PubMed PMID: 26465374. 3. Braun D, Baquet M, Massberg S, Mehilli J, Hausleiter J. Collapse of a Bioresorbable Novolimus-Eluting Coronary Scaffold. JACC Cardiovasc Interv. 2016 Jan 11;9(1):e13-e14. doi: 10.1016/j.jcin.2015.10.019. Epub 2015 Dec 9. PubMed PMID: 26685077. 4. Amber KI, Hadi NR, Muhammad-Baqir BM, Jamil DA, Al-Aubaidy HA. Trimetazidine attenuates the acute inflammatory response induced by Novolimus eluting bioresorbable coronary scaffold implantation. Int J Cardiol. 2016 Oct 1;220:514-9. doi: 10.1016/j.ijcard.2016.06.172. Epub 2016 Jun 27. PubMed PMID: 27390979.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

7-O-Demethyl rapamycin 151519-50-5 CJ 12263 CJ12263 7-O-Demethyl Rapammune 7ODemethyl rapamycin Novolimus (80%) 7-O-Demethyl Cypher Novolimus 7 O Demethyl rapamycin CJ-12263 inhibitor inhibit

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